Arginine
Other Name(s):
a-amino-d-guanidino-n-valeric acid
Unsubstantiated Claims:
Please note that this section reports on claims that have NOT yet been substantiated through scientific studies.
Arginine is claimed to improve fertility in men by increasing sperm count. It may also help stimulate the output of human growth hormone (HGH) and increase collagen in connective tissue.
Arginine may be helpful in reducing fatigue, improving wound healing, increasing muscle mass and treating diabetes and liver disease.
There are some indications that arginine may be useful in the fight against cancer and play a role in the treatment of AIDS.
Recommended Intake:
Amino acids (AAs) are available as individual AAs or in proprietary AA combinations, as well as part of multi-vitamin formulas, proteins and food supplements. The forms include tablets, fluids and powders. However, adequate protein in the diet should provide a sufficient source of all amino acids.
There are no conditions that increase the requirements for arginine. However, newborns do have higher requirements than adults.
Side Effects, Toxicity and Interactions:
The use of a single amino acid supplement may lead to negative nitrogen balance, decreasing the metabolic efficiency and increasing the workload of the kidneys. In children, taking single amino acid supplements may also harmfully affect growth parameters.
Always avoid taking individual amino acids in high dosage for prolonged periods.
Women who are pregnant or breast-feeding should not use arginine supplements.
Children and adolescents should not use arginine supplements. Individuals with an active herpes infection also should avoid using arginine.
Additional Information:
Click here for a list of reputable Web sites with general information on nutrition.
References:
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Weast RC, Astle MJ, Beyer WH, eds. Handbook of Chemistry and Physics. 65th ed. Boca Raton, FL: CRC Press, Inc.; 1984.
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Lide DR, Frederikse HPR, eds. Handbook of Chemistry and Physics. 75th ed. Boca Raton, FL: CRC Press, Inc.; 1994.
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Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper's Biochemistry. 25th ed. Stamford, CT: Appleton & Lange; 2000.
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Meisenberg G, Simmons WH. Principles of Medical Biochemistry. Mosby Pub. Co.; 1998.
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Styer L. Biochemistry. 4th ed. W.H. Freeman & Co.; 1995.
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Montgomery R, Conway TW, Spector AA, Chappell D. Biochemistry: A Case-Oriented Approach. 6th ed. Mosby Pub. Co.; 1996.